About Neurogenomics
Mouse Lines
Research Vocabulary
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Preliminary Assessments


Learning and Memory

Psychostimulant Response

Circadian Rhythmicity

Vision and Eye


Center for Functional Genomics at Northwestern University

National Institutes of Health

Protocols ›› Circadian Rhythmicity

Although nine genes have been proposed to be components of the mouse circadian clock, definitive genetic evidence for their participation is not available for the majority of these genes. For example, the null mutants of mPer1 and mPer3 produced by gene targeting do not reveal an abnormal circadian phenotype. To understand the function of the known genes implicated in circadian regulation and to discover new circadian genes, we will screen 10,000 progeny of mutagenized mice per year for circadian rhythms by measuring locomotor activity rhythms.

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