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November 10, 2005 - View the NIH Neurogenomics Project scientific poster (#228) at Neuroscience 2005 on Sun, Nov 13 at 8am - 12pm.

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Center for Functional Genomics at Northwestern University

National Institutes of Health

The NIH Neurogenomics Project at Northwestern University

The NIH Neurogenomics Project at Northwestern University, directed by Dr. Joseph S. Takahashi, conducts a genome-wide, phenotype-driven, N-ethyl-N-nitrosourea (ENU) mutagenesis screen for mouse mutations.

The NIH Neurogenomics Project collaborates with The Neuroscience Mutagenesis Facility at The Jackson Laboratory and the Neuromutagenesis Project of the Tennessee Mouse Genome Consortium to form a consortium known as Neuromice.org. This consortium has a collective purpose to detect, characterize and distribute new mouse mutants with neurological and behavioral phenotypes.

Mouse Line Highlights

More lines can be found at Neuromice.org.

Name Mode of Inheritance Description Status
biga1 Recessive A-wave of electroretinogram (ERG) is almost twice the normal peak amplitude at 12 weeks of age. Other waves are normal. Pending
Mighty Mouse Dominant Increased body mass as compared to a normal mouse; longer body length as compared to normal mouse Pending
pisa Recessive Mutant animals lean to one side. Some circling behavior is observed, but is not pronounced. Hearing appears unaffected. Available Live
serg1 Recessive All waves of ERG are undetectable or very small at 12 weeks of age. Pending
Short-time Semidominant Free running period approximately one hour shorter than wild-type mice Pending

Mutagenesis Breeding and Phenotyping

Genome-wide mutagenesis is accomplished with the chemical ENU. A three-generation breeding scheme is used to produce mice homozygous for induced mutations. To date, >13,000 mice have been produced and phenotypically screened. Production and screening are continuing.

Mice are tested in a series of phenotypic screens focused on 5 domains. An additional set of supplemental assays comprise a “preliminary assessment.”