More terms are available in a glossary used at The Jackson Laboratory.
- A type of genetic cross in which a hybrid strain is crossed to one of the two parental strains.
- Forward Genetics
- Comparing to reverse genetic approach, in which mutations are produced by replacement of a gene, forward genetic approach uses mutagenesis to produce a gene mutation and perform screening procedures to study gene function.
- the genetic constitution of an organism, as distinguished from its physical appearance (its phenotype).
- The capability of a trait being passed from one generation to the next
- Treatment of a group of cells or organisms with a mutagen as a means of inducing mutations.
- A term applied to a gene, phenotype or organism altered by mutation.
- the observable properties of an organism; produced by the genotype in conjunction with the environment.
- Used by forward genetics, phenotypic screens are designed to identify heritable abnormalities of an organism which are mutagenized using a mutagenesis approach. The mutation is mapped and gene function is therefore discovered.
- Offspring or descendants considered as a group
- Stands for putative mutant. Mice exhibit an altered phenotype, but the heritability of the phenotype is not confirmed.